Cranial neural crest-derived mesenchymal proliferation is regulated by msx1-mediated p19ink4d expression during odontogenesis
نویسندگان
چکیده
منابع مشابه
Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest
The epithelial-to-mesenchymal transition (EMT) is a highly coordinated process underlying both development and disease. Premigratory neural crest cells undergo EMT, migrate away from the neural tube, and differentiate into diverse cell types during vertebrate embryogenesis. Adherens junction disassembly within premigratory neural crest cells is one component of EMT and, in chick cranial neural ...
متن کاملTGFbeta-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development.
The murine frontal bone derives entirely from the cranial neural crest (CNC) and consists of the calvarial (lateral) aspect that covers the frontal lobe of brain and the orbital aspect that forms the roof of bony orbit. TGFbeta and FGF signaling have important regulatory roles in postnatal calvarial development. Our previous study has demonstrated that conditional inactivation of Tgfbr2 in the ...
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The origin of active predation in vertebrates is associated with the rise of three major, uniquely derived developmental characteristics of the head: (i) migratory cranial neural crest cells (CNCCs) giving rise to most skeletal skull elements; (ii) expression of Dlx genes by CNCCs in the Hox-free first pharyngeal arch (PA1); and (iii) muscularization of PA1 derivatives. Here we show that these ...
متن کاملEpithelial-mesenchymal Interactions during Odontogenesis
Recently we reported ultrastructural observatlons which indicated that matrix vesicles were actual constituents of the intercellular organic matrix during embryonic tooth development (14). It is assumed that many of these matrix vesicles are involved in formative aspects of dentinogenesis or amelogenesis, two primary extracellular processes that occur during embryonic tooth formation The fracti...
متن کاملCombined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest.
The neural crest is a multipotent, migratory cell population that contributes to a variety of tissues and organs during vertebrate embryogenesis. Here, we focus on the function of Msx1 and Msx2, homeobox genes implicated in several disorders affecting craniofacial development in humans. We show that Msx1/2 mutants exhibit profound deficiencies in the development of structures derived from the c...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2003
ISSN: 0012-1606
DOI: 10.1016/s0012-1606(03)00300-2